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1

Direct Activation of PDE5 by cGMP: Long-Term Effects within NO/cGMP Signaling

Florian Mullershausen, Andreas Friebe, Robert Feil, W. Joseph Thompson, Franz Hofmann and Doris Koesling

Journal:

The Journal of Cell Biology

Year:

2003

Language:

english

File:

PDF, 1.97 MB

english, 2003

2

Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways

Mullershausen, F., Lange, A., Mergia, E., Friebe, A., Koesling, D.

Journal:

Molecular Pharmacology

Year:

2006

Language:

english

File:

PDF, 194 KB

english, 2006

3

Desensitisation of NO/cGMP signalling in vascular and bronchial smooth muscle

Alexander Lange, Florian Müllershausen, Andreas Friebe, Doris Koesling

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

4

NO/cGMP signalling

Doris Koesling, Evanthia Mergia, Michael Russwurm, Florian Mullershausen, Corina Wagner, Alexander Lange, Andreas Friebe

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

5

Design and characterization of FRET-based cGMP indicators

Michael Russwurm, Florian Mullershausen, Andreas Friebe, Ronald Jäger, Corina Russwurm, Doris Koesling

Journal:

BMC Pharmacology

Year:

2007

Language:

english

File:

PDF, 189 KB

english, 2007

6

Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors

Florian Mullershausen, Luis M. Craveiro, Youngah Shin, Marta Cortes-Cros, Frederic Bassilana, Maribel Osinde, William L. Wishart, Danilo Guerini, Michaela Thallmair, Martin E. Schwab, Rajeev Sivasanka

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 1019 KB

english, 2007

7

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

Mullershausen, Florian, Zecri, Frédéric, Cetin, Cihan, Billich, Andreas, Guerini, Danilo, Seuwen, Klaus

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 534 KB

english, 2009

8

Corrigendum: Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

Mullershausen, Florian, Zecri, Frédéric, Cetin, Cihan, Billich, Andreas, Guerini, Danilo, Seuwen, Klaus

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 47 KB

english, 2009

9

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

Kumlesh K. Dev, Florian Mullershausen, Henri Mattes, Rainer R. Kuhn, Graeme Bilbe, Daniel Hoyer, Anis Mir

Journal:

Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

10

The enhanced NO-induced cGMP response induced by long-term l-NAME treatment is not due to enhanced expression of NO-sensitive guanylyl cyclase

Florian Müllershausen, Michael Russwurm, Doris Koesling, Andreas Friebe

Journal:

Vascular Pharmacology

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

11

Exogenous Nitric Oxide Donation Causes Desensitization of Arteriolar Relaxing Activity In Vivo: An Intravital Analysis in Mice

Andrej Ring, Florian Mullershausen, Ole Goertz, Doris Koesling, Gert Muhr, Hans-Ulrich Steinau, Lars Steinstraesser, Stefan Langer

Journal:

Journal of Surgical Research

Year:

2010

Language:

english

File:

PDF, 469 KB

english, 2010

12

Nitric oxide-sensitive guanylyl cyclase: structure and regulation

Doris Koesling, Michael Russwurm, Evanthia Mergia, Florian Mullershausen, Andreas Friebe

Journal:

Neurochemistry International

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

13

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors

Maribel Osinde, Florian Mullershausen, Kumlesh K. Dev

Journal:

Neuropharmacology

Year:

2007

Language:

english

File:

PDF, 1.00 MB

english, 2007

14

Negative feedback in NO/cGMP signalling

Koesling, D., Mullershausen, F., Lange, A., Friebe, A., Mergia, E., Wagner, C., Russwurm, M.

Journal:

Biochemical Society Transactions

Year:

2005

Language:

english

File:

PDF, 172 KB

english, 2005

15

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P 1 receptor internalization

Sykes, David A, Riddy, Darren M, Stamp, Craig, Bradley, Michelle E, McGuiness, Neil, Sattikar, Afrah, Guerini, Danilo, Rodrigues, Ines, Glaenzel, Albrecht, Dowling, Mark R, Mullershausen, Florian, Cha

Journal:

British Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

16

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes

Healy, Luke M, Sheridan, Graham K, Pritchard, Adam J, Rutkowska, Aleksandra, Mullershausen, Florian, Dev, Kumlesh K

Journal:

British Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 4.11 MB

english, 2013

17

Inhibition of Phosphodiesterase Type 5 by the Activator of Nitric Oxide-Sensitive Guanylyl Cyclase BAY 41-2272

Mullershausen, F.

Journal:

Year:

2004

Language:

english

File:

PDF, 321 KB

english, 2004

18

In Vivo Reconstitution of the Negative Feedback in Nitric Oxide/cGMP Signaling: Role of Phosphodiesterase Type 5 Phosphorylation

Mullershausen, F.

Journal:

Molecular Biology of the Cell

Year:

2004

Language:

english

File:

PDF, 256 KB

english, 2004

19

Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

Mullershausen, F.

Journal:

The Journal of Cell Biology

Year:

2001

Language:

english

File:

PDF, 172 KB

english, 2001

20

Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling

Mullershausen, F.

Journal:

The Journal of Cell Biology

Year:

2003

Language:

english

File:

PDF, 305 KB

english, 2003

21

Rapid Nitric Oxide-Induced Desensitization of the cGMP Response Is Caused by Increased Activity of Phosphodiesterase Type 5 Paralleled by Phosphorylation of the Enzyme

Florian Mullershausen, Michael Russwurm, W. Joseph Thompson, Li Liu, Doris Koesling and Andreas Friebe

Journal:

The Journal of Cell Biology

Year:

2001

Language:

english

File:

PDF, 1.77 MB

english, 2001

22

Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach

Russwurm, Michael, Mullershausen, Florian, Friebe, Andreas, Jäger, Ronald, Russwurm, Corina, Koesling, Doris

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 493 KB

english, 2007

23

Negative feedback in NO/cGMP signalling

Koesling, D., Mullershausen, F., Lange, A., Friebe, A., Mergia, E., Wagner, C., Russwurm, M.

Journal:

Biochemical Society Transactions

Year:

2005

Language:

english

File:

PDF, 172 KB

english, 2005

24

NO-sensitive guanylyl cyclase and NO-induced feedback inhibition in cGMP signaling

Mullershausen, Florian,

Journal:

Frontiers in Bioscience

Year:

2005

Language:

english

File:

PDF, 392 KB

english, 2005